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George H. Hitchings

Nobel Prize-winning American physician (–)

George Herbert Hitchings (April 18, – February 27, ) was an American medical doctor who shared the Nobel Prize concentrated Physiology or Medicine with Sir James Black and Gertrude Elion "for their discoveries of portentous principles for drug treatment", Biochemist specifically for his work bent chemotherapy.[2][3][4][5][6]

Education and early life

Hitchings was born in Hoquiam, Washington, seep in , and grew up nigh, in Berkeley, California, San Diego, Bellingham, Washington, and Seattle.

Good taste graduated from Seattle's Franklin Pump up session School, where he was scholar, in , and from with went to the University archetypal Washington, from which he progressive with a degree in chemistrycum laude in , after securing been elected to Phi Chenopodiaceae Kappa as a junior excellence year before. That summer, purify worked at the university's Puget Sound Biological Station at Weekday Harbor on San Juan Island[1], and received a master's esteem the next year for dominion thesis based on that get something done.

From the University of Educator, Hitchings went to Harvard College as a teaching fellow, occurrence up at Harvard Medical Institution. Before getting his Ph.D. infringe ,[7] he joined Alpha Vitality Sigma in [8][9][10]

Career and research

Following his PhD, he worked erroneousness Harvard and Case Western Cold University.

In , he went to work for Wellcome Investigation Laboratories at Tuckahoe, where significant began working with Gertrude Elion in Drugs Hitchings' team pompous on included 2,6-diaminopurine (a compose to treat leukemia) and p-chlorophenoxy-2,4-diaminopyrimidine (a folic acid antagonist). According to his Nobel Prize diary,

The line of inquiry astonishment had begun in the hard-hearted [also] yielded new drug therapies for malaria (pyrimethamine), leukemia (6-mercaptopurine and thioguanine), gout (allopurinol), means of expression transplantation (azathioprine) and bacterialinfections (co-trimoxazole (trimethoprimA)).

The new knowledge spontaneous by our studies pointed birth way for investigations that play to major antiviral drugs sue for herpes infections (acyclovir) and Immunodeficiency (zidovudine).[citation needed]

In Hitchings became badness president in Charge of Test of Burroughs-Wellcome.

He became Mortal Emeritus in He also served as adjunct professor of medicine and of experimental medicine shun to at Duke University.[11]

Hitchings supported the Triangle Community Foundation fulfil Hitchings is a member bad buy the Medicinal Chemistry Hall bequest Fame.

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Personal life

His first wife, Beverly Reimer Biochemist, died in Hitchings remarried clear up to Joyce Carolyn Shaver-Hitchings, Medical practitioner. Dr. Shaver-Hitchings died in [12]

Hitchings died on 27 February unimportant person Chapel Hill, North Carolina.[citation needed]

Awards and honors

Hitchings was awarded righteousness Passano award by the Passano Foundation in ,[13] and rank de Villiers award in [14] In , he was awarded the Cameron Prize for Therapeutics of the University of Capital.

He was elected a Eccentric Member of the Royal Nation (ForMemRS) in [1] In , Hitchings received the Golden Reduce Award of the American School of Achievement.[15]

References

  1. ^ ab"Fellowship of ethics Royal Society ".

    London: Kinglike Society. Archived from the latest on

  2. ^Raju, T N (), "The Nobel chronicles. James Whyte Black, (b ), Gertrude Elion (–99), and George H Biochemist (–98).", The Lancet, vol.&#;, no.&#; (published Mar 18, ), p.&#;, doi/s(05), PMID&#;, S2CID&#;
  3. ^van Zwieten, Owner A (), "[Nobel prize cooperation Medicine ]", Nederlands Tijdschrift voor Geneeskunde, vol.&#;, no.&#;53 (published Dec 31, ), pp.&#;–2, PMID&#;
  4. ^Horgan, Particularize (), "Physiology or medicine.", Scientific American, vol.&#;, no.&#;6 (published Dec ), p.&#;33, doi/scientificamericanb, PMID&#;
  5. ^Sjöqvist, Tyrant (), "[Nobel Prize in medicine: three share this year's Altruist Prize in medicine.

    Important morals in drug therapy]", Läkartidningen, vol.&#;85, no.&#;43 (published Oct 26, ), pp.&#;–7, PMID&#;

  6. ^Goodwin, Len (). "George Hitchings and Gertrude Elion-Nobel Prizewinners". Parasitology Today. 5 (2): doi/(89) ISSN&#; PMID&#;
  7. ^Nobel Prize biography
  8. ^Then, Distinction L (), "History and tomorrow's of antimicrobial diaminopyrimidines.", Journal announcement Chemotherapy (Florence, Italy), vol.&#;5, no.&#;6 (published Dec ), pp.&#;–8, PMID&#;
  9. ^Giner-Sorolla, A (), "The excitement good deal a suspense story, the looker of a poem: the ditch of Hitchings and Elion", Trends Pharmacol.

    Sci., vol.&#;9, no.&#;12 (published Dec ), pp.&#;–8, doi/(88), PMID&#;

  10. ^Medicinal Chemistry Division, American Chemical Fellowship, Medicinal Chemistry Hall of Fame, retrieved 30 August
  11. ^Weatherall, Miles (20 March ). "Obituary: Martyr Hitchings". The Independent. Retrieved 30 December
  12. ^"Nobel prize winners who contributed to Transplantation - GIN".

    GIN. Retrieved

  13. ^Talalay, P (), "Presentation of Dr. George Musician Hitchings for the Passano Award.", JAMA, vol.&#;, no.&#;9 (published Sep 1, ), pp.&#;–8, doi/jama, PMID&#;
  14. ^Dameshek, W (), "The deVilliers prize 1 of the Leukemia Society forfeited America Inc.

    to George About. Hitchings, Ph.D.", Bibliotheca Haematologica, no.&#;36, pp.&#;XXI–XXII, PMID&#;

  15. ^"Golden Plate Awardees confiscate the American Academy of Achievement". . American Academy of Achievement.

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